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ylinda

peggissue
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Dear Hannah,

According to the research that you've mentioned in a reference:

Kimball, A. B., Kaczvinsky, J. R., Li, J., Robinson, L. R., Matts, P. J.Berge, C. A.Miyamoto, K.)Bissett, D. L. (2010) Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. British J Dermatology 162: 435-441

I would like to mix niacinamide with glucosamine to treat my 1-year old melasma. Can you please suggest how should I mix them assuming I buy both ingredients from your web site. Which proportions? How to mix them? What should I use as a base cream? How to store the cream?

And also - if I make this mix and use it twice per day, do you think I should also apply your SBC or LMC? If yes - please let me know the suggested regime.

Many thanks,
Linda
hannah

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Reply with quote  #2 
Hi Linda, welcome to our forum!

It matters whether the hyperpigmentation is from sun damage or melasma. In your case, what is it?
ylinda

peggissue
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According to my derm doctor its melasma;-(
hannah

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From the paper:
Subjects in the niacinamide plus NAG group received a topical night-time cream formulation containing 4% niacinamide plus 2% NAG and a topical daytime lotion formulation which also contained 4% niacinamide plus 2% NAG, plus sufficient sunscreen agents [1% Parsol HS (phenylbenzimidazole sulphonic acid) and 2% Parsol 1789 (avobenzone)] to achieve sun protection factor (SPF) 15, broad-spectrum protection.
ylinda

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Reply with quote  #5 
Thank you, Hannah!

If possible, I'd like to clarify few things to make sure I understood correctly:

1) According to the percentage you've mentioned I'd have to mix the whole tube (5 gr) niacinamide with half tube (2.5 gr.) NAG in a 120 gr. of a base cream. Is this correct?

2) The research mentioned that it should be mixed in a lotion. Is there any issue if I mix it in my (all natural) day moisturizer cream and not in a lotion? Does it matter?

3) An important question - is any of these ingredients (niacinamide or NAG) photo sensitive (meaning if I apply it in the morning and go outside it could make my skin prone to more hyper pigmentation? Or is it better to apply the mix only during the night?

4) Do you know if I need to wash it off some time after I apply it or just leave it on my skin ?

5) Is this a permanent kind of treatment? (meaning the melanin generation is inhibited as long as I use it and the moment I stop using the mix the hyper pigmentation returns?)
 
6) And last - for how long can I safely use this combination on my skin? 2-3-4 months? longer? do you know any side effects of this in a longer daily usage?

Thank you for your help and sorry for so many questions, I am very novice to all this do-it-yourself thing and just want to get it right;-)

Linda

 

hannah

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Reply with quote  #6 
I managed to hit my head this morning (don't ask but just make sure you have a bath mat outside your shower) so I am not going to check your calculations. I am sure they are right.

Lotion, cream, serum, whatever dissolves the actives will do. No need to rinse off.

Niacinamide and N-acetyl glucosamine are not photo sensitive.

You can use this combination for as long as you wish, unless you see any worrying changes. I don't think you will.

Melasma is very difficult to treat. Some remedies (e.g. hydroquinone) are not worth the risks. I don't think this particular combination will fix melasma, but it may help you. Look at all the actives and ready-mixed products we sell for melasma!  If there was a miracle cure,  there would not be a need for more actives to treat it.

I don't think that a mechanism of action has been established for this actives. Just try and see whether they work for you and make sure you wear sunscreen and avoid the sun as much as you can.



ylinda

peggissue
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Reply with quote  #7 
Thanks so much, Hannah!
lydiam0013

peggissue
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Reply with quote  #8 
Quote:
Originally Posted by hannah
Hi Linda, welcome to our forum!

It matters whether the hyperpigmentation is from sun damage or melasma. In your case, what is it?


Hello Hannah,

Hoping you could help me.  In the forum you provide the amounts needs to create the niacinamide and glucosamine together for melasma, but not for sun damage.  Can you provide that?

Thank you for your help.

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Lydia
hannah

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Reply with quote  #9 
I spent a lot of time reading on hyperpigmentation during the last two months. I am not convinced that you can treat the two "conditions" as separate entities. The whole process is too complex and it is not that clear how they differ. Or, maybe it is clear how they differ initially but not in treatment.

I'm afraid that my article was so long and boring that Jonatan cut it a lot. I am not sure that what remains is enough to understand the process of normal pigmentation and what goes wrong in melasma and sun spots. I will ask Jonatan to publish the whole thing on the forum so whoever is interested can read it.
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